Estimation of Allele and Haplotype Frequencies for 23 YSTR Markers in the Lebanese Population
ثبت نشده
چکیده
Y-STR analysis may in certain cases complement the autosomal STR markers in forensic, investigations, kinship testing and human identification. Hence, it would be informative to assess the probability of occurrence of the Y-STR haplotype in the Lebanese population where. This study aimed at estimating the Lebanese Y-STR allele and haplotype frequencies in 502 non-related males using the Y-filer Kit (Applied Biosystems) which includes the nine minimal Y-STR haplotype: DYS19, DYS390, DYS391, DYS392, DYS393, DYS389I/II, DYS385a/b plus 14 other Y-STR loci: DYS437, DYS438, DYS439, DYS456, DYS456, DYS448, Y-GATA-H4, DYS576, DYS570, DYS549, DYS643, DYS533 and DYS481. All 23 Y-STR loci were highly polymorphic with the marker DYS385a/b being the most polymorphic. 489 different haplotypes were defined where 476 (94.8%) carried a unique haplotype and the most common haplotypes appeared twice. This database has a discrimination capacity of 97.4% and a haplotype diversity of 0.9999%. The obtained data serves as an essential prerequisite for using Y-chromosomal STR in routine forensic practice in the Lebanese population where the endogamy rate average is 88%.
منابع مشابه
Estimation of Allele and Haplotype Frequencies for 23 YSTR Markers in the Lebanese Population
Y-STR analysis may in certain cases complement the autosomal STR markers in forensic, investigations, kinship testing and human identification. Hence, it would be informative to assess the probability of occurrence of the Y-STR haplotype in the Lebanese population where. This study aimed at estimating the Lebanese Y-STR allele and haplotype frequencies in 502 non-related males using the Y-filer...
متن کاملUGT1A1 gene linkage analysis: application of polymorphic markers rs4148326/rs4124874 in the Iranian population
Objective(s): Mutations in the UGT1A1 gene are responsible for hyperbilirubinemia syndromes including Crigler-Najjar type 1 and 2 and Gilbert syndrome. In view of the genetic heterogeneity and involvement of large numbers of the disease causing mutations, the application of polymorphic markers in the UGTA1 gene could be useful in molecular diagnosis of the disease. Materials and Methods: In the...
متن کاملHardy Weinberg Equilibrium Testing and Interpretation: Focus on infection
Hardy-Weinberg equilibrium (HWE) holds when, in a closed population with random mating and without mutation and natural selection, genotype frequencies at any locus is a simple function of allele frequencies. Testing for HWE is now a common practice in population genetics and genetic association studies of non-communicable diseases; however, it is less-regarded, or sometimes miss-interpreted, i...
متن کاملHeterozygosis deficit of polymorphic markers linked to the β-globin gene cluster region in the Iranian population
Objective(s): Iran is considered as one of the high-prevalence areas for β-thalassemia with a rate of about 10% carrier frequency. Molecular diagnosis of the disease is performed both by direct sequencing and indirectly by the use of polymorphic markers present in the beta globin gene cluster. However, to date there is no reliable information on the application of the markers in the Iranian pop...
متن کاملThe Allele and Genotype Frequencies of Bovine Pituitaryspecific Transcription Factor and Leptin Genes in IranianCattle and Buffalo Populations Using PCR-RFLP
The use of polymorphic markers in breeding programmes could make selection more accurate and efficient. A total of 324 individuals from six Iranian cattle populations (Sarabi, Golpayegani, Sistani, Taleshi, Mazandarani, Dashtiyari), F1 Golpayegani × Brown Swiss and Iranian buffalo populations were genotypedfor the Pit-1 HinfI and leptin Sau3AI polymorphisms by the polymerase chain reactio...
متن کامل